AVVISO IMPORTANTE

Online Registrations will open on April 17 and can only be made via the following platform: hemoglobinopaties2021.govirtual.it


Certificate of Attendance
will be available for all participants who attend the webinar

Information for foreign delegates 

In order to require the recognition of CME credits, foreign healthcare professionals can submit to their professional order the useful documentation (such as ID, certificate of attendance, program of the event and dedicated request form). The professional order will evaluate the event and the possible recognition of the credits.


LIVE EDITION

8 May from 01:35pm till 06:05pm (ROME TIME/CEST)

  • Patrocinatore
  • Patrocinatore
  • Con la sponsorizzazione non condizionante di
  • Con la sponsorizzazione non condizionante di
  • Con la sponsorizzazione non condizionante di
  • Con la sponsorizzazione non condizionante di
  • Con la sponsorizzazione non condizionante di

Presentazione

RATIONALE

In recent years, there has been a swift evolution in development of innovative therapies for the management of thalassemia and sickle cell disease (SCD). Global collaborations have helped transition many of these advances from the bench to the bedside, with gradual integration into routine clinical practice. Conventional therapies have served patients with hemoglobinopathies for decades and significantly improved survival outcomes. Thus, it remains imperative to revisit the holistic care of patients and identify optimal strategies to merge the ‘old’ with the ‘new’ in the management of the individual patient.

On this International Thalassemia Day, we gather global experts and opinion leaders to discuss various updates in disease understanding and management for patients with hemoglobinopathies. Emerging insights on molecular pathways and clinical forms will be discussed. These would then lead the way to an overview and deep interpretation of novel data from clinical trials of bone marrow transplant, gene therapy, genome editing, and other agents that target the ineffective erythropoiesis and iron dysregulation in thalassemia, as well as sickling, hemolysis and vasculopathy in SCD. We will end the day with sharing experiences on managing patients with hemoglobinopathies during the Covid-19 pandemic. 

Programma

Rome Time (CEST)

13.25|13.30        Welcome to participants and opening remarks

                              Aurelio Maggio (Italy)-Khaled Musallam (UK)-Vijay Sankaran (USA)

 

SESSION 1

Moderators: Aurelio Maggio (Italy); Antonis Kattamis (Greece)

13.30|13.50        Ali Taher (Lebanon)

Modern understanding of clinical forms and determinants of outcomes in thalassemia

  • Conventional and new classifications
  • The role of anemia/transfusions, iron overload/chelation in shaping disease prospect

 

13.50|14.10        Baba Inusa (UK)

Pathophysiology and clinical correlates in SCD: status quo

  • Overview of key novel insights into pathophysiology of SCD
  • Clinical observations in children and adults

 

14.10|14.30        Vijay Sankaran (USA)

Thalassemia and SCD from the eye of molecular pathology

  • Correlations between genotypes and hematologic/clinical profiles
  • Key discoveries in molecular pathways that reshaped our understanding of disease

              

14.30|14.45        Q&A - Interactive discussion on the topics of the current session (Faculty)

 

SESSION 2

Moderators: Giuliana Ferrari (Italy); Vijay Sankaran (USA)

             

14.45|15.05        John Tisdale (USA)

Bone marrow transplant in hemoglobinopathies: what have we achieved over the years?

  • Review of outcomes data
  • Developments in strategy and technique

 

15.05|15.25        Franco Locatelli (Italy)

Gene therapy: progress so far

  • Available approaches and protocols
  • Current data and ongoing/future trials

 

15.25|15.45        Josu De La Fuente (UK)

Gene editing: the new kid on the block

  • Available approaches and protocols
  • Current data and ongoing/future trials

 

15.45|16.05        Gianluca Forni (Italy)

Decisional algorithm for gene therapy: recommendations from “SITE”

  • Clinical profile of the ideal candidate for gene therapy
  • Main recommendations for enrollment

 

16.05|16.20        Q&A - Interactive discussion on the topics of the current session (Faculty)

 

SESSION 3

 

Moderators: Khaled Musallam (UK); Ali Taher (Lebanon)

 

16.20|16.40        Vip Viprakasit (Thailand)

Targeting ineffective erythropoiesis and iron dysregulation in thalassemia: evolving strategies

  • Rationale and pathways
  • Updates from animal studies and ongoing/future trials of novel agents

             

16.40|17.00        Maria Cappellini (Italy)

Luspatercept: optimal integration into clinical practice

  • Overall program direction and recent data
  • Real-life practical implementation

              

17.00|17.20        Elliott Vichinsky (USA)

Advances in management of SCD: agents on the horizon

  • Updates on experience with HU
  • New drugs in development

              

17.20|17.35        Q&A - Interactive discussion on the topics of the current session (Faculty)      

 

SESSION 4

 

Moderator: Michael Angastiniotis (Cyprus)

 

17.35|17.55        Mehran Karimi (Iran)

Hemoglobinopathies and Covid-19: should we be concerned?

  • Experience and challenges
  • Strategies and solutions

              

17.55|18.00        Q&A - Interactive discussion on the topics of the current session (Faculty)

 

18.00|18.05        Take home messages and concluding remarks

Aurelio Maggio (Italy), Khaled Musallam (UK), Vijay Sankaran (USA)

Informazioni

Obiettivo formativo

2 - Linee guida - protocolli - procedure

Mezzi tecnologici necessari

Internet Connection, Computer/Tablet

Procedure di valutazione

CME Evaluation Test

Responsabili

Responsabile scientifico

  • Prof. AURELIO MAGGIO
    Responsabile Hub Regionale UOC Ematologia II con Talassemia - AO Ospedali Riuniti Villa Sofia-Cervello Palermo

Docente

  • Prof.ssa MARIA DOMENICA CAPPELLINI
    Professore ordinario di Medicina Interna - Università degli Studi Milano
  • Dott. GIANLUCA FORNI
    Responsabile Medico di Ematologia - Ospedali Galliera - Genova
  • Prof. BABA INUSA
    Consultant and associate professor of paediatric haematology Guy's and St Thomas' NHS Trust - London
  • Prof. MEHRAN KARIMI
    Prof. of Pediatric Hematology Oncology -Hematology Research Center - Pediatric Oncology Department, Amir Hospital-Shiraz,Iran
  • Prof. FRANCO LOCATELLI
    Head, Professor Department of Pediatric Onco-Hematology and Transfusion Medicine, Ospedale Pediatrico Bambino Gesù - Rome
  • Prof. AURELIO MAGGIO
    Responsabile Hub Regionale UOC Ematologia II con Talassemia - AO Ospedali Riuniti Villa Sofia-Cervello Palermo

Tutor

  • Prof. AURELIO MAGGIO
    Responsabile Hub Regionale UOC Ematologia II con Talassemia - AO Ospedali Riuniti Villa Sofia-Cervello Palermo

Moderatore

  • Dott. MICHAEL ANGASTINIOTIS
    TIF Medical Advisor - Thalassemia International Federation (TIF) - Cyprus
  • Prof.ssa GIULIANA FERRARI
    Prof.of Molecular Biology and Gene Expression-S. Raffaele Telethon Institute for Gene Therapy - Milano
  • Prof. ANTONIS KATTAMIS
    President, Hellenic Society of Pediatric Hematology-Oncology-National and Kapodistrian University of Athens
  • Prof. KHALED MOUSA SALEH MUSALLAM
    President, International Network of Hematology, London, UK
  • Prof. VIJAY G SANKARAN
    BOSTON CHILDREN'S HOSPITAL DANA-FARBER CANCER INSTITUTE - HARVARD MEDICAL SCHOOL - MA, USA
  • Prof. ALI TAHER
    Prof. of Haematology, Director of Department of Internal Medicine, American University of Beirut- Medical Centre-Beirut
  • Prof. JOHN F TISDALE
    Senior Investigator - Cellular and Molecular Therapeutics Branch NIH ( NATIONAL HEART, LUNG, BLOOD INSTITUTE)-MD USA
  • Prof. VIP VIPRAKASIT
    Associate Professor of Haematology, Division of Paediatric Haematology/Oncology at Siriraj Hospital, Mahidol University-Bangkok

Elenco delle professioni e discipline a cui l'evento è rivolto

Medico chirurgo

  • Ematologia
  • Medicina trasfusionale
  • Pediatria
  • Pediatria (pediatri di libera scelta)

Biologo

  • Biologo

Infermiere

  • Infermiere

Tecnico sanitario laboratorio biomedico

  • Tecnico sanitario laboratorio biomedico
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