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Presentazione

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for pediatric patients with many hematological diseases. The indications for HSCT in children are well defined for acute leukemia, as well as for patients with non-malignant disease. HSCT from HLA-identical sibling or unrelated donors, such as new techniques of graft manipulation using haploidentical donor graft, provides a high chance of cure for those patients. The field of HSCT is rapidly evolving with the possibility to perform targeted immunotherapy with CAR-T cells for acute lymphoblastic leukemia, B-cell lymphomas and solid tumors. More recently, the first results of gene therapy for hereditary diseases, open new perspectives of treatment for patients with thalassemia, sickle cell disease, primary immune-deficiencies and metabolic disorders

 

Goals

The meeting will address all the relevant aspects of indication and results of HSCT in pediatric population, focusing on new insights on gene therapy for hereditary diseases, as well as on the newest results obtained through approaches of immunotherapy. Ethical and regulatory aspects related to these new therapies will be discussed, as well.

Recognized, outstanding international leaders will deliver the main lectures, but also high-level research talks selected from the best abstracts submitted by attendees will be presented.

Programma

 

                         Welcome to participants and opening remarks  -   F. Locatelli

 

45 min.            Gene therapy of stem cells for inherited, rare neurological disorders -  A. Biffi

 

45 min.            Gene therapy in hemoglobinopathies  - F. Locatelli

 

45 min.            Immunotherapy approaches in stem cell transplantation  - L. Moretta

 

45 min.            Current indications of stem cell transplantation in children -  P. Bader

 

45 min.            Resistance to CAR T immunotherapy in hematologic malignancies  -  M. Ruella

 

                          CME questionnaire

 

Informazioni

Obiettivo formativo

2 - Linee guida - protocolli - procedure

Mezzi tecnologici necessari

Internet Connection, Computer/tablet

Procedure di valutazione

CME Evaluation Test

Responsabili

Responsabile scientifico

  • Prof. FRANCO LOCATELLI
    Head, Professor Department of Pediatric Onco-Hematology and Transfusion Medicine, Ospedale Pediatrico Bambino Gesù - Rome

Docente

  • Prof. PETER BADER
    Head; Division for Stem Cell Transplantation, Immunology and Intensive Care Medicine University Hospital Frankfurt - Frankfurt
  • Prof.ssa ALESSANDRA BIFFI
    Full Professor Of Pediatrics University Of Padova - Padova
  • Prof. FRANCO LOCATELLI
    Head, Professor Department of Pediatric Onco-Hematology and Transfusion Medicine, Ospedale Pediatrico Bambino Gesù - Rome
  • Prof. LORENZO MORETTA
    Research Director, Head Of Department Ospedale Pediatrico Bambin Gesù - Rome
  • Prof. MARCO RUELLA
    Assistant Professor UNIVERSITY OF PENNSYLVANIA, MEDICINE, HEMATOLOGY-ONCOLOGY, PHILADELPHIA Philadelphia, PA USA

Elenco delle professioni e discipline a cui l'evento è rivolto

Medico chirurgo

  • Allergologia ed immunologia clinica
  • Anestesia e rianimazione
  • Biochimica clinica
  • Ematologia
  • Malattie Infettive
  • Medicina trasfusionale
  • Microbiologia e virologia
  • Oncologia
  • Pediatria

Biologo

  • Biologo

Tecnico sanitario laboratorio biomedico

  • Tecnico sanitario laboratorio biomedico
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